Literature summary for 4.1.2.13 extracted from

Macomber, L.; Elsey, S.P.; Hausinger, R.P.
Fructose-1,6-bisphosphate aldolase (class II) is the primary site of nickel toxicity in Escherichia coli (2011), Mol. Microbiol., 82, 1291-1300.

Search for more literature for 4.1.2.13

Protein Variants

Protein Variants	Comment	Organism
D144A	residue is involved in ligating the secondary zinc atom. Mutant exhibits enhancement of enzymatic activity by added nickel	Escherichia coli
E174A	residue is involved in ligating the secondary zinc atom. Mutant is insensitive to nickel	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
Ni2+	cells stressed by 8 microM Ni(II) for 20 min lose 75% of their FbaA activity. In presence of 8 microM Ni(II), purified FbaA loses 80% of its activity within 2 min. Inhibition is due to Ni(II) binding to a secondary zinc binding site	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Synonyms

Synonyms	Comment	Organism
FbaA	-	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)