Literature summary for 4.1.2.13 extracted from

Mabiala-Bassiloua, C.G.; Zwolinska, M.; Therisod, H.; Sygusch, J.; Therisod, M.
Separate synthesis and evaluation of D-glucitol 1,6-bisphosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases (2008), Bioorg. Med. Chem. Lett., 18, 1735-1737.

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Application

Application	Comment	Organism
medicine	inhibitors of class II Fba can be potential drugs against microorganisms	Saccharomyces cerevisiae
medicine	inhibitors of class II Fba can be potential drugs against microorganisms	Helicobacter pylori

Inhibitors

Inhibitors	Comment	Organism	Structure
D-glucitol 1,6-bisphosphate	competitive inhibitor	Helicobacter pylori
D-glucitol 1,6-bisphosphate	competitive inhibitor	Oryctolagus cuniculus
D-glucitol 1,6-bisphosphate	competitive inhibitor, better inhibitor	Saccharomyces cerevisiae
D-mannitol 1,6-bisphosphate	competitive inhibitor, better inhibitor	Helicobacter pylori
D-mannitol 1,6-bisphosphate	competitive inhibitor	Oryctolagus cuniculus
D-mannitol 1,6-bisphosphate	competitive inhibitor	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.02	-	D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus
0.2	-	D-fructose 1,6-bisphosphate	-	Saccharomyces cerevisiae
20	-	D-fructose 1,6-bisphosphate	-	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	P56109	-	-
Oryctolagus cuniculus	P00883	-	-
Saccharomyces cerevisiae	P14540	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
D-fructose 1,6-bisphosphate	-	Helicobacter pylori	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
D-fructose-1,6-bisphosphate	-	Saccharomyces cerevisiae	dihydroxyacetone phosphate + glyceraldehyde-3-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
class I Fba	-	Oryctolagus cuniculus
class I muscle fructose bis-phosphate aldolase	-	Oryctolagus cuniculus
class II aldolase	-	Saccharomyces cerevisiae
class II aldolase	-	Helicobacter pylori
FBA	-	Oryctolagus cuniculus
FBA	-	Saccharomyces cerevisiae
FBA	-	Helicobacter pylori
fructose bis-phosphate aldolase	-	Oryctolagus cuniculus
fructose bis-phosphate aldolase	-	Saccharomyces cerevisiae
fructose bis-phosphate aldolase	-	Helicobacter pylori

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0073	-	D-mannitol 1,6-bisphosphate	-	Oryctolagus cuniculus
0.06	-	D-glucitol 1,6-bisphosphate	-	Saccharomyces cerevisiae
0.073	-	D-mannitol 1,6-bisphosphate	-	Helicobacter pylori
0.1	-	D-glucitol 1,6-bisphosphate	-	Oryctolagus cuniculus
0.17	-	D-glucitol 1,6-bisphosphate	-	Helicobacter pylori
0.4	-	D-mannitol 1,6-bisphosphate	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)