Literature summary for 4.1.1.9 extracted from

Samokhvalov, V.; Ussher, J.R.; Fillmore, N.; Armstrong, I.K.; Keung, W.; Moroz, D.; Lopaschuk, D.G.; Seubert, J.; Lopaschuk, G.D.
Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance (2012), Am. J. Physiol. Endocrinol. Metab., 303, E1459-E1468.

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Inhibitors

Inhibitors	Comment	Organism	Structure
methyl-5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) phenyl)morpholine-4-carboxamido)pentanoate	i.e. CBM-301106, specific inhibitor of the enzyme	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiomyocyte	neonatal	Mus musculus	-
heart	-	Mus musculus	-
macrophage	peritoneal	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
MCD	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	pharmacological inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance. Additionally, inhibition of MCD strongly diminishes lipopolysaccharide-induced activation of palmitate oxidation and prevents lipopolysaccharide-induced collapse of total cellular antioxidant capacity and prevents increases in the level of ceramide in cardiomyocytes and macrophages while also ameliorating LPS-initiated decreases in PPAR binding. Genetic inactivation of malonyl-CoA decarboxylase protects mice against high-fat diet-induced insulin resistance	Mus musculus
physiological function	malonyl-CoA decarboxylase regulates fatty acid oxidation	Mus musculus

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Release 2023.1 (January 2023)