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Literature summary for 4.1.1.9 extracted from

  • Voilley, N.; Roduit, R.; Vicaretti, R.; Bonny, C.; Waeber, G.; Dyck, J.R.B.; Lopaschuk, G.D.; Prentki, M.
    Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase (1999), Biochem. J., 340, 213-217.
No PubMed abstract available
Search for more literature for 4.1.1.9

Cloned(Commentary)

Cloned (Comment) Organism
from pancreatic beta cell line INS-1, expression in human kidney 293 cells, sequencing Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix INS-1 MCD, expression most likely in, contains an N-terminal mitochondrial targeting sequence Rattus norvegicus 5759
-
peroxisome INS-1 MCD, expression most likely inside, the C-terminal part of enzyme ends with a peroxisomal targeting motif Rattus norvegicus 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54700
-
 x * 54700, recombinant INS-1 MCD, enzyme might multimerize in vivo, calculated from the amino acid sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Malonyl-CoA Rattus norvegicus role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release Acetyl-CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rat
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information INS-1 MCD, sequence shows multiple possible sites of phosphorylation by casein kinase II and protein kinase C, no acylation sites Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
 Rattus norvegicus Acetyl-CoA + CO2
-
 ?
Malonyl-CoA role in detoxification by preventing malonyl-CoA accumulation catalysed by propionyl -CoA carboxylase, in pancreatic beta cells MCD might act as an off signal for insulin release Rattus norvegicus Acetyl-CoA + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 54700, recombinant INS-1 MCD, enzyme might multimerize in vivo, calculated from the amino acid sequence Rattus norvegicus