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Literature summary for 4.1.1.9 extracted from
- Malonyl-CoA decarboxylase from Mycobacterium tuberculosis and Pseudomonas fluorescence (1979), Arch. Biochem. Biophys., 196, 543-551.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Mycobacterium tuberculosis |  |
| acetyl-CoA | insensitive | Pseudomonas fluorescens | |
| Avidin | no inhibition | Mycobacterium tuberculosis | |
| CoA | - |
Mycobacterium tuberculosis | |
| CoA | - |
Pseudomonas fluorescens | |
| methylmalonyl-CoA | - |
Mycobacterium tuberculosis | |
| p-hydroxymercuribenzoate | insensitive | Pseudomonas fluorescens | |
| propionyl-CoA | - |
Mycobacterium tuberculosis | |
| propionyl-CoA | insensitive | Pseudomonas fluorescens | |
| succinyl-CoA | - |
Mycobacterium tuberculosis | |
| succinyl-CoA | - |
Pseudomonas fluorescens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
malonyl-CoA | - |
Mycobacterium tuberculosis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44000 | - |
gel filtration | Mycobacterium tuberculosis |
| 56000 | - |
gel filtration | Pseudomonas fluorescens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis H37Ra / ATCC 25177 | - |
- |
- |
| Pseudomonas fluorescens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Pseudomonas fluorescens |
| partially | Mycobacterium tuberculosis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.396 | - |
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Malonyl-CoA | - |
Pseudomonas fluorescens | Acetyl-CoA + CO2 | - |
? | |
| Malonyl-CoA | - |
Mycobacterium tuberculosis | Acetyl-CoA + CO2 | - |
? | |
| Malonyl-CoA | - |
Mycobacterium tuberculosis H37Ra / ATCC 25177 | Acetyl-CoA + CO2 | - |
? | |
| methylmalonyl-CoA | at 5% of the activity with malonyl-CoA | Mycobacterium tuberculosis | propionyl-CoA + CO2 | - |
? | |
| methylmalonyl-CoA | at 5% of the activity with malonyl-CoA | Mycobacterium tuberculosis H37Ra / ATCC 25177 | propionyl-CoA + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Pseudomonas fluorescens |
| 5.5 | - |
- |
Mycobacterium tuberculosis |
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