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Literature summary for 4.1.1.9 extracted from
- Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland (1978), Arch. Biochem. Biophys., 190, 234-246.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Rattus norvegicus |  |
| methylmalonyl-CoA | - |
Rattus norvegicus | |
| NEM | - |
Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| propionyl-CoA | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.054 | - |
malonyl-CoA | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 160000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Malonyl-CoA | Rattus norvegicus | decarboxylates malonyl-CoA generated by propionyl-CoA carboxylase and thus protects mitochondrial enzymes susceptible to inhibition by malonyl-CoA | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| mammary gland | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 16.46 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Malonyl-CoA | - |
Rattus norvegicus | Acetyl-CoA + CO2 | - |
? | |
| Malonyl-CoA | decarboxylates malonyl-CoA generated by propionyl-CoA carboxylase and thus protects mitochondrial enzymes susceptible to inhibition by malonyl-CoA | Rattus norvegicus | ? | - |
? | |
| methylmalonyl-CoA | no reaction | Rattus norvegicus | propionyl-CoA + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | 10 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 10 | pH 4.5: about 40% of maximal activity, pH 8.5-10: optimum, less than 10% of maximal activity at pH 10.5 | Rattus norvegicus |
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