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Literature summary for 4.1.1.48 extracted from

  • Zaccardi, M.J.; Mannweiler, O.; Boehr, D.D.
    Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-glycerol phosphate synthase enzymes at their adaptive temperatures (2012), Biochem. Biophys. Res. Commun., 418, 324-329.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate at pH 7.5 and 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate Escherichia coli
-
 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 Escherichia coli 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
IGPS
-
 Escherichia coli
indole-3-glycerol phosphate synthase
-
 Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1
-
 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate at pH 7.5 and 25°C Escherichia coli
9.3
-
 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate at pH 7.5 and 37°C Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
5700
-
 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate at pH 7.5 and 37°C Escherichia coli