Literature summary for 4.1.1.48 extracted from

Andreotti, G.; Cubellis, M.V.; di Palo, M.; Fessas, D.; Sannia, G.; Marino, G.
Stability of a thermophilic TIM-barrel enzyme: indole-3-glycerol phosphate synthase from the thermophilic archaeon Sulfolobus solfataricus (1997), Biochem. J., 323, 259-264.

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General Stability

General Stability	Organism
guanidinium-induced denaturation. Unfolding mechanism closely approaches a two-state model at pH 7.0 and a more complex mechanism at pH 9.0	Saccharolobus solfataricus

Organism

Organism	UniProt	Comment	Textmining
Saccharolobus solfataricus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate	-	Saccharolobus solfataricus	1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O	-	?

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	melting temperature is higher at alkaline that at neutral pH	Saccharolobus solfataricus
80	-	first-order kinetic constant at pH 6.5, pH 8.0 and pH 9.5: 0.020 per min	Saccharolobus solfataricus

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
additional information	-	melting temperature is higher at alkaline that at neutral pH	Saccharolobus solfataricus

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Release 2023.1 (January 2023)