Application | Comment | Organism |
---|---|---|
medicine | Because epileptic attacks can be treated with appropriate antiepileptic drugs, a confirmation whether patients with AADC deficiency have both non-epileptic and epileptic seizures in varying proportions, is necessary. The differentiation of epileptic seizures from involuntary non-epileptic movements, such as short-lasting dystonic attacks, chorea, or myoclonus, is indispensable for the adequate treatment of patients with AADC deficiency. | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-Dihydroxyphenylalanine | Homo sapiens | enzyme is involved in the biosynthesis of monoamine neurotransmitters | Dopamine + CO2 | - |
? | |
5-hydroxytryptophan | Homo sapiens | - |
5-hydroxytryptamine + CO2 | serotonin | ? | |
additional information | Homo sapiens | aromatic L-amino acid decarboxylase deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,4-Dihydroxyphenylalanine | enzyme is involved in the biosynthesis of monoamine neurotransmitters | Homo sapiens | Dopamine + CO2 | - |
? | |
5-hydroxytryptophan | - |
Homo sapiens | 5-hydroxytryptamine + CO2 | serotonin | ? | |
additional information | aromatic L-amino acid decarboxylase deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AADC | - |
Homo sapiens |
Aromatic L-amino acid decarboxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |