Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor 4-(2-hydroxy-4-methoxyphenyl)-4-oxobutanoic acid, to 2.1 A resolution. The inhibitor molecule occupies a part of the active site that overlaps with the phosphate-binding region in the OMP- or UMP-bound complexes. The carboxyl group of the inhibitor causes a dramatic movement of the L1 and L2 loops that play a role in the recognition of the substrate and product molecules | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-hydroxy-4-methoxyphenyl)-4-oxobutanoic acid | the inhibitor molecule occupies a part of the active site that overlaps with the phosphate-binding region in the OMP- or UMP-bound complexes. The carboxyl group of the inhibitor causes a dramatic movement of the L1 and L2 loops that play a role in the recognition of the substrate and product molecules | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8T6J6 | - |
- |