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Literature summary for 4.1.1.23 extracted from

  • Meza-Avina, M.E.; Wei, L.; Liu, Y.; Poduch, E.; Bello, A.M.; Mishra, R.K.; Pai, E.F.; Kotra, L.P.
    Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase (2010), Bioorg. Med. Chem., 18, 4032-4041.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Staphylococcus aureus
-
Homo sapiens
-
Saccharomyces cerevisiae
-
Methanothermobacter thermautotrophicus
-
Helicobacter pylori
-
Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with 4 and 10) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Saccharomyces cerevisiae
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Staphylococcus aureus
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Homo sapiens
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Methanothermobacter thermautotrophicus
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Helicobacter pylori
hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
5-cyano-UMP poor inhibition Helicobacter pylori
5-cyano-UMP poor inhibition Homo sapiens
5-cyano-UMP poor inhibition Methanothermobacter thermautotrophicus
5-cyano-UMP poor inhibition Plasmodium falciparum
5-cyano-UMP poor inhibition Saccharomyces cerevisiae
5-cyano-UMP poor inhibition Staphylococcus aureus
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Helicobacter pylori
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Homo sapiens
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Methanothermobacter thermautotrophicus
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Plasmodium falciparum
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Saccharomyces cerevisiae
barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Staphylococcus aureus
nifedipine competitive inhibition Helicobacter pylori
nifedipine competitive inhibition Homo sapiens
nifedipine competitive inhibition Methanothermobacter thermautotrophicus
nifedipine competitive inhibition Plasmodium falciparum
nifedipine competitive inhibition Saccharomyces cerevisiae
nifedipine competitive inhibition Staphylococcus aureus
nimodipine competitive inhibition Helicobacter pylori
nimodipine competitive inhibition Homo sapiens
nimodipine competitive inhibition Methanothermobacter thermautotrophicus
nimodipine competitive inhibition Plasmodium falciparum
nimodipine competitive inhibition Saccharomyces cerevisiae
nimodipine competitive inhibition Staphylococcus aureus
pyrazofurin also known as pyrazomycin, potent inhibitor Helicobacter pylori
pyrazofurin also known as pyrazomycin, potent inhibitor Homo sapiens
pyrazofurin also known as pyrazomycin, potent inhibitor Methanothermobacter thermautotrophicus
pyrazofurin also known as pyrazomycin, potent inhibitor Plasmodium falciparum
pyrazofurin also known as pyrazomycin, potent inhibitor Saccharomyces cerevisiae
pyrazofurin also known as pyrazomycin, potent inhibitor Staphylococcus aureus
pyrazofurin-5'-monophosphate slow tight binding inhibitor Helicobacter pylori
pyrazofurin-5'-monophosphate slow tight binding inhibitor Homo sapiens
pyrazofurin-5'-monophosphate slow tight binding inhibitor Methanothermobacter thermautotrophicus
pyrazofurin-5'-monophosphate slow tight binding inhibitor Plasmodium falciparum
pyrazofurin-5'-monophosphate slow tight binding inhibitor Saccharomyces cerevisiae
pyrazofurin-5'-monophosphate slow tight binding inhibitor Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0017
-
orotidine 5'-phosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Homo sapiens
0.0037
-
orotidine 5'-phosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Methanothermobacter thermautotrophicus

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Homo sapiens
-
-
-
Methanothermobacter thermautotrophicus
-
-
-
Plasmodium falciparum
-
-
-
Saccharomyces cerevisiae
-
-
-
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Staphylococcus aureus
-
Homo sapiens
-
Saccharomyces cerevisiae
-
Methanothermobacter thermautotrophicus
-
Helicobacter pylori
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Orotidine 5'-phosphate
-
Staphylococcus aureus UMP + CO2
-
?
Orotidine 5'-phosphate
-
Homo sapiens UMP + CO2
-
?
Orotidine 5'-phosphate
-
Saccharomyces cerevisiae UMP + CO2
-
?
Orotidine 5'-phosphate
-
Methanothermobacter thermautotrophicus UMP + CO2
-
?
Orotidine 5'-phosphate
-
Helicobacter pylori UMP + CO2
-
?
Orotidine 5'-phosphate
-
Plasmodium falciparum UMP + CO2
-
?

Synonyms

Synonyms Comment Organism
ODCase
-
Staphylococcus aureus
ODCase
-
Homo sapiens
ODCase
-
Saccharomyces cerevisiae
ODCase
-
Methanothermobacter thermautotrophicus
ODCase
-
Helicobacter pylori
ODCase
-
Plasmodium falciparum
Orotidine-5'-monophosphate decarboxylase
-
Staphylococcus aureus
Orotidine-5'-monophosphate decarboxylase
-
Homo sapiens
Orotidine-5'-monophosphate decarboxylase
-
Saccharomyces cerevisiae
Orotidine-5'-monophosphate decarboxylase
-
Methanothermobacter thermautotrophicus
Orotidine-5'-monophosphate decarboxylase
-
Helicobacter pylori
Orotidine-5'-monophosphate decarboxylase
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000009
-
barbiturate ribonucleoside 5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Saccharomyces cerevisiae
0.000005
-
pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Saccharomyces cerevisiae
0.000017
-
pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Homo sapiens
0.00013
-
pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Helicobacter pylori
0.0062
-
pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Methanothermobacter thermautotrophicus
9.1
-
5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Plasmodium falciparum
290
-
5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Helicobacter pylori
550
-
5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Staphylococcus aureus