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Literature summary for 4.1.1.23 extracted from

  • Kotra, L.P.; Pai, E.F.
    Inhibition of orotidine-5-monophosphate decarboxylase--discoveries and lessons (2008), Nucleic Acids Symp. Ser., 52, 85-86.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-aminouridine 5'-monophosphate
-
Homo sapiens
6-aminouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
6-aminouridine 5'-monophosphate
-
Plasmodium falciparum
6-aminouridine 5'-monophosphate
-
Staphylococcus aureus
6-azidouridine 5'-monophosphate
-
Homo sapiens
6-azidouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
6-azidouridine 5'-monophosphate
-
Plasmodium falciparum
6-azidouridine 5'-monophosphate
-
Staphylococcus aureus
6-cyanouridine 5'-monophosphate
-
Homo sapiens
6-cyanouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
6-cyanouridine 5'-monophosphate
-
Plasmodium falciparum
6-cyanouridine 5'-monophosphate
-
Staphylococcus aureus
6-iodouridine 5'-monophosphate
-
Helicobacter pylori
6-iodouridine 5'-monophosphate
-
Homo sapiens
6-iodouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
6-iodouridine 5'-monophosphate
-
Plasmodium falciparum
6-iodouridine 5'-monophosphate
-
Staphylococcus aureus
6-methyl-uridine
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Orotidine 5'-phosphate Staphylococcus aureus
-
UMP + CO2
-
?
Orotidine 5'-phosphate Homo sapiens
-
UMP + CO2
-
?
Orotidine 5'-phosphate Helicobacter pylori
-
UMP + CO2
-
?
Orotidine 5'-phosphate Plasmodium falciparum
-
UMP + CO2
-
?
Orotidine 5'-phosphate Methanothermobacter thermautotrophicus
-
UMP + CO2
-
?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Homo sapiens
-
-
-
Methanothermobacter thermautotrophicus O26232
-
-
Plasmodium falciparum
-
-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-cyanouridine 5'-monophosphate pseudohydrolysis process Staphylococcus aureus 6-hydroxyuridine 5'-monophosphate + CN-
-
?
6-cyanouridine 5'-monophosphate pseudohydrolysis process Homo sapiens 6-hydroxyuridine 5'-monophosphate + CN-
-
?
6-cyanouridine 5'-monophosphate pseudohydrolysis process Plasmodium falciparum 6-hydroxyuridine 5'-monophosphate + CN-
-
?
6-cyanouridine 5'-monophosphate pseudohydrolysis process Methanothermobacter thermautotrophicus 6-hydroxyuridine 5'-monophosphate + CN-
-
?
Orotidine 5'-phosphate
-
Staphylococcus aureus UMP + CO2
-
?
Orotidine 5'-phosphate
-
Homo sapiens UMP + CO2
-
?
Orotidine 5'-phosphate
-
Helicobacter pylori UMP + CO2
-
?
Orotidine 5'-phosphate
-
Plasmodium falciparum UMP + CO2
-
?
Orotidine 5'-phosphate
-
Methanothermobacter thermautotrophicus UMP + CO2
-
?

Synonyms

Synonyms Comment Organism
ODCase
-
Staphylococcus aureus
ODCase
-
Homo sapiens
ODCase
-
Helicobacter pylori
ODCase
-
Plasmodium falciparum
ODCase
-
Methanothermobacter thermautotrophicus
Orotidine-5'-monophosphate decarboxylase
-
Staphylococcus aureus
Orotidine-5'-monophosphate decarboxylase
-
Homo sapiens
Orotidine-5'-monophosphate decarboxylase
-
Helicobacter pylori
Orotidine-5'-monophosphate decarboxylase
-
Plasmodium falciparum
Orotidine-5'-monophosphate decarboxylase
-
Methanothermobacter thermautotrophicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00019
-
6-azidouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
0.00084
-
6-aminouridine 5'-monophosphate
-
Methanothermobacter thermautotrophicus
0.002
-
6-azidouridine 5'-monophosphate
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0044
-
chloroquine-resistant strain Plasmodium falciparum 6-iodouridine 5'-monophosphate
0.0062
-
chloroquine-sensitive strain Plasmodium falciparum 6-iodouridine 5'-monophosphate
0.5305
-
-
Plasmodium falciparum 6-methyl-uridine