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Literature summary for 4.1.1.23 extracted from

  • Poduch, E.; Bello, A.M.; Tang, S.; Fujihashi, M.; Pai, E.F.; Kotra, L.P.
    Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics (2006), J. Med. Chem., 49, 4937-4945.
    View publication on PubMed
Search for more literature for 4.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
1-methylorotate modeling of binding and structure Methanothermobacter thermautotrophicus
6-amino-1-methyluracil modeling of binding and structure Methanothermobacter thermautotrophicus
6-amino-UMP competitive inhibition Methanothermobacter thermautotrophicus
6-aza-UMP competitive inhibition Methanothermobacter thermautotrophicus
6-cyano-1-methyluracil modeling of binding and structure Methanothermobacter thermautotrophicus
6-cyano-UMP competitive inhibition Methanothermobacter thermautotrophicus
6-hydroxy-1-methyl uracil modeling of binding and structure Methanothermobacter thermautotrophicus
barbituric acid monophosphate i.e. 6-hydroxy-UMP Methanothermobacter thermautotrophicus
additional information inhibitor synthesis, overview Methanothermobacter thermautotrophicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Methanothermobacter thermautotrophicus
0.005
-
 orotidine 5'-phosphate pH 7.5, 55°C Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Orotidine 5'-phosphate Methanothermobacter thermautotrophicus
-
 UMP + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also converts 6-cyano-UMP to barbituric acid monophosphate with low activity Methanothermobacter thermautotrophicus ?
-
 ?
Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODCase
-
 Methanothermobacter thermautotrophicus
Orotidine monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
 assay at Methanothermobacter thermautotrophicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
21
-
 orotidine 5'-phosphate pH 7.5, 55°C Methanothermobacter thermautotrophicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Methanothermobacter thermautotrophicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, isothermal calorimetry Methanothermobacter thermautotrophicus
0.00084
-
 6-amino-UMP pH 7.5, 55°C Methanothermobacter thermautotrophicus
0.0124
-
 6-aza-UMP pH 7.5, 55°C Methanothermobacter thermautotrophicus
0.029
-
 6-cyano-UMP pH 7.5, 55°C Methanothermobacter thermautotrophicus