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Literature summary for 4.1.1.23 extracted from

  • Capone, R.F.; Ning, Y.; Pakulis, N.; Alhazzazi, T.; Fenno, J.C.
    Characterization of Treponema denticola pyrF encoding orotidine-5-monophosphate decarboxylase (2007), FEMS Microbiol. Lett., 268, 261-267.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene pyrF, organization in the pyr operon, DNA and amino acid sequence determination and analysis, expression analysis, expression in Escherichia coli Treponema denticola

Protein Variants

Protein Variants Comment Organism
additional information construction of a null mutant, allelic replacement mutagenesis of pyrF, phenotype, overview, unlike the wild-type strain, an isogenic pyrF mutant is resistant to 5-fluoroorotic acid Treponema denticola

Inhibitors

Inhibitors Comment Organism Structure
Uracil strong feedback inhibition Treponema denticola

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Treponema denticola the enzyme is required for 5-fluoroorotic acid toxicity ?
-
?
Orotidine 5'-phosphate Treponema denticola the enzyme is required for de novo pyrimidine synthesis catalyzing the key final step in de novo synthesis of UMP UMP + CO2
-
?

Organism

Organism UniProt Comment Textmining
no activity in Treponema pallidum
-
-
-
Treponema denticola
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strain ATCC 35405, single copy gene pyrF or TDE2110
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is required for 5-fluoroorotic acid toxicity Treponema denticola ?
-
?
Orotidine 5'-phosphate
-
Treponema denticola UMP + CO2
-
?
Orotidine 5'-phosphate the enzyme is required for de novo pyrimidine synthesis catalyzing the key final step in de novo synthesis of UMP Treponema denticola UMP + CO2
-
?

Synonyms

Synonyms Comment Organism
OMP decarboxylase
-
Treponema denticola
orotidine-5-monophosphate decarboxylase
-
Treponema denticola