Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.23 extracted from

  • Shoaf, W.T.; Jones, M.E.
    Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of six biosynthetic enzymes (1973), Biochemistry, 12, 4039-4051.
    View publication on PubMed
Search for more literature for 4.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
6-azauridine 5'-phosphate
-
 Mus musculus
UMP product inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008 0.009 orotidine 5'-phosphate
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000 115000 bifunctional enzyme that contains activities of EC 2.4.2.10 and EC 4.1.1.23, sucrose density gradient centrifugation with 30% dimethyl sulfoxide and 5% glycerol Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Orotidine 5'-phosphate Mus musculus required for the biosynthesis of uridylic acid ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 bifunctional UMP synthase contains activities of EC 2.4.2.10 and EC 4.1.1.23
-

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Orotidine 5'-phosphate
-
 Mus musculus UMP + CO2
-
 ?
Orotidine 5'-phosphate required for the biosynthesis of uridylic acid Mus musculus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
6 8 about 50% of maximal acticity at pH 6.0 and 8.0 Mus musculus