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Literature summary for 4.1.1.22 extracted from

  • Deng, X.; Wu, X.; Yu, Z.; Arai, I.; Sasano, T.; Sugawara, S.; Endo, Y.
    Inductions of histidine decarboxylase in mouse tissues following systemic antigen challenge: contributions made by mast cells, non-mast cells and IL-1 (2007), Int. Arch. Allergy Immunol., 144, 69-78.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information antigen challenge induces HDC in both mast cell-dependent and mast cell-independent ways at a postanaphylactic time in the liver, lung, spleen, and ears, enzyme activity is increased in atissue-dependent manner after sensitization of wild-type mice by ovalbumin, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Mus musculus HDC induction may contribute to the replenishment of the reduced pool of mast cell histamine in the anaphylactic period histamine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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wild-type BALB/c mice, mast cell-deficient W/W v mice, and IL-1-KO BALB/c mice, deficient in both Iinterleukin-1alpha and interleukin-1beta
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Source Tissue

Source Tissue Comment Organism Textmining
ear
-
Mus musculus
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liver
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Mus musculus
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lung
-
Mus musculus
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spleen
-
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
Mus musculus histamine + CO2
-
?
L-histidine HDC induction may contribute to the replenishment of the reduced pool of mast cell histamine in the anaphylactic period Mus musculus histamine + CO2
-
?

Synonyms

Synonyms Comment Organism
HDC
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus