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Literature summary for 4.1.1.22 extracted from

  • Fleming, J.V.; Sanchez-Jimenez, F.; Moya-Garcia, A.A.; Langlois, M.R.; Wang, T.C.
    Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches (2004), Biochem. J., 379, 253-261.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.22

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzymes expressed in Escherichia coli Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
DELTA517-656 C-terminall truncated enzyme is fully active Rattus norvegicus
DELTA517-656/C104S activity is significantly decreased relative to wild-type enzyme Rattus norvegicus
DELTA517-656/C115S activity is significantly decreased relative to wild-type enzyme Rattus norvegicus
DELTA517-656/C254S activity is significantly decreased relative to wild-type enzyme Rattus norvegicus
DELTA517-656/C316S activity is significantly decreased relative to wild-type enzyme Rattus norvegicus
DELTA517-656/D276G no activity detectable Rattus norvegicus
DELTA517-656/H197G activity is 11.8fold lower than wild-type activity Rattus norvegicus
DELTA517-656/K308G no activity detectable Rattus norvegicus
DELTA517-656/Q343G344ins no activity detectable Rattus norvegicus
DELTA517-656/Q343ins activity is 2.3fold lower than wild-type activity Rattus norvegicus
DELTA517-656/S307G activity is 13.4fold lower than wild-type activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Rattus norvegicus