Literature summary for 4.1.1.22 extracted from

Schelp, E.; Worley, S.; Monzingo, A.F.; Ernst, S.; Robertus, J.D.
pH-induced structural changes regulate histidine decarboxylase activity in Lactobacillus 30a (2001), J. Mol. Biol., 306, 727-732.

Activating Compound

Activating Compound	Comment	Organism	Structure
pyruvate	-	Lactobacillus sp.

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of active HDC at pH 4.8 at 2.5 A resolution, crystal structure of less active HDC at pH 8.0 at 2.7 A resolution, crystals are grown at room temperatur by hanging-drop vapor diffusion, drops contain 0.004 ml HDC at 12.5 mg/ml, 0.001 ml n-dodecyl-beta-D-maltoside and 0.005 ml precipitant solution from the well containing 25% polyethylene glycol 400, 8% polyethylene glycol 400, 100 mM Tris pH 8.0, and 100 mM sodium acetate, enzyme activity is regulated by pH-induced structural changes	Lactobacillus sp.

Crystallization (Comment)

Organism

crystal structure of active HDC at pH 4.8 at 2.5 A resolution, crystal structure of less active HDC at pH 8.0 at 2.7 A resolution, crystals are grown at room temperatur by hanging-drop vapor diffusion, drops contain 0.004 ml HDC at 12.5 mg/ml, 0.001 ml n-dodecyl-beta-D-maltoside and 0.005 ml precipitant solution from the well containing 25% polyethylene glycol 400, 8% polyethylene glycol 400, 100 mM Tris pH 8.0, and 100 mM sodium acetate, enzyme activity is regulated by pH-induced structural changes

Lactobacillus sp.

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.3	-	L-histidine	pH 4.8	Lactobacillus sp.
100	-	L-histidine	pH 7.0	Lactobacillus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-histidine	Lactobacillus sp.	-	histamine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Lactobacillus sp.	P00862	30a	-

Purification (Commentary)

Purification (Comment)	Organism
-	Lactobacillus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-histidine	-	Lactobacillus sp.	histamine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
HDC	-	Lactobacillus sp.

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Release 2023.1 (January 2023)