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Literature summary for 4.1.1.22 extracted from

  • Toledo, A.; Sabria, J.; Rodriguez, R.; Brandner, R.; Rodriguez, J.; Palacios, J.M.; Blanco, I.
    Properties and ontogenic development of membrane-bound histidine decarboxylase from rat brain (1988), J. Neurochem., 51, 1400-1406.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.43
-
 L-His membrane-bound enzyme Rattus norvegicus
0.46
-
 L-His solublilized membrane-bound enzyme Rattus norvegicus
0.52
-
 L-His soluble enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
soluble
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-His
-
 Rattus norvegicus Histamine + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 soluble and membrane-associated enzyme Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8 pH 5.5: about 35% of maximal activity, pH 8.0: about 10% of maximal activity, membrane-bound enzyme Rattus norvegicus
5.5 8 pH 5.5: about 50% of maximal activity, pH 8.0: about 40% of maximal activity, soluble enzyme Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate Km for pyridoxal 5'-phosphate with soluble enzyme: 0.00243 mM. Km for pyridoxal 5'-phosphate with membrane-bound enzyme: 0.00296 mM. Km for pyridoxal 5'-phosphate with solubilized membrane-bound enzyme: 0.00286 mM Rattus norvegicus