Any feedback?
Literature summary for 4.1.1.22 extracted from
- Purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylase from Klebsiella planticola and Enterobacter aerogenes (1987), J. Bacteriol., 169, 3963-3968.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Fluoromethylhistidine | - |
Klebsiella aerogenes |  |
| alpha-Fluoromethylhistidine | - |
Morganella morganii | |
| alpha-Fluoromethylhistidine | - |
Raoultella planticola | |
| alpha-Methylhistidine | - |
Klebsiella aerogenes | |
| alpha-Methylhistidine | - |
Morganella morganii | |
| alpha-Methylhistidine | - |
Raoultella planticola | |
| carnosine | - |
Klebsiella aerogenes | |
| carnosine | - |
Morganella morganii | |
| carnosine | - |
Raoultella planticola | |
| Cyanoborohydride | - |
Morganella morganii | |
| dithiothreitol | - |
Klebsiella aerogenes | |
| dithiothreitol | - |
Morganella morganii | |
| dithiothreitol | - |
Raoultella planticola | |
| Histidine methyl ester | - |
Klebsiella aerogenes | |
| Histidine methyl ester | - |
Raoultella planticola | |
| Hydrazine sulfate | - |
Klebsiella aerogenes | |
| Hydrazine sulfate | - |
Raoultella planticola | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.1 | - |
L-His | - |
Morganella morganii | |
| 2.2 | - |
L-His | - |
Klebsiella aerogenes | |
| 2.4 | - |
L-His | - |
Raoultella planticola | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42500 | - |
2 * and 4 * 42500, SDS-PAGE | Raoultella planticola |
| 42500 | - |
4 * and 2 * 42500, SDS-PAGE | Raoultella planticola |
| 50000 | - |
2 * 50000, SDS-PAGE | Klebsiella aerogenes |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella aerogenes | - |
- |
- |
| Morganella morganii | - |
- |
- |
| Morganella morganii AM-15 | - |
- |
- |
| Raoultella planticola | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Klebsiella aerogenes |
- |
Raoultella planticola |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 121 | - |
- |
Klebsiella aerogenes |
| 123 | - |
- |
Raoultella planticola |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-His | - |
Klebsiella aerogenes | Histamine + CO2 | - |
? | |
| L-His | - |
Morganella morganii | Histamine + CO2 | - |
? | |
| L-His | - |
Raoultella planticola | Histamine + CO2 | - |
? | |
| L-His | - |
Morganella morganii AM-15 | Histamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 50000, SDS-PAGE | Klebsiella aerogenes |
| dimer | 2 * and 4 * 42500, SDS-PAGE | Raoultella planticola |
| tetramer | - |
Morganella morganii |
| tetramer | 4 * and 2 * 42500, SDS-PAGE | Raoultella planticola |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Klebsiella aerogenes |
| 6.5 | - |
- |
Morganella morganii |
| 6.5 | - |
- |
Raoultella planticola |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Morganella morganii | |
| pyridoxal 5'-phosphate | contains 1 mol of pyridoxal 5'-phosphate per mol of subunit | Klebsiella aerogenes | |
| pyridoxal 5'-phosphate | contains 1 mol of pyridoxal 5'-phosphate per mol of subunit | Raoultella planticola | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
