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Literature summary for 4.1.1.22 extracted from
- Properties of histidine decarboxylase from rat gastric mucosa (1982), Eur. J. Biochem., 123, 593-599.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Hydroxy-5-nitrobenzylbromide | - |
Rattus norvegicus |  |
| Co2+ | 0.1 mM, 20% decrease of activity | Rattus norvegicus | |
| Cu2+ | 0.1 mM, strong inhibition | Rattus norvegicus | |
| Cys | - |
Rattus norvegicus | |
| dithiothreitol | - |
Rattus norvegicus | |
| Hg2+ | 0.1 mM, strong inhibition | Rattus norvegicus | |
| histamine | at high concentrations | Rattus norvegicus | |
| NEM | - |
Rattus norvegicus | |
| Ni2+ | 0.1 mM, 15% decrease of activity | Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
| pyridoxal 5'-phosphate | non-competitive inhibition with respect to His, at high concentrations | Rattus norvegicus | |
| reduced glutathione | - |
Rattus norvegicus | |
| Semicarbazide | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe3+ | 0.1 mM, enhances activity by 7-8% | Rattus norvegicus | |
| Mn2+ | 0.1 mM, enhances activity by 7-8% | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-His | strictly specific for L-His | Rattus norvegicus | Histamine + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 56 | - |
- |
Rattus norvegicus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 47 | 60 | 47°C: about 50% of maximal activity, 60°C: about 75% of maximal activity, no activity detectable at 65°C | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
stable for at least 30 min, without pyridoxal 5'-phosphate | Rattus norvegicus |
| 50 | - |
40% loss of activity after 30 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate | Rattus norvegicus |
| 55 | - |
50% loss of activity in 13 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate | Rattus norvegicus |
| 57 | - |
50% loss of activity in 4 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate | Rattus norvegicus |
| 60 | - |
50% loss of activity in 2 min, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate | Rattus norvegicus |
| 64 | - |
50% loss of activity in 30 s, 5fold increase of half-life in presence of saturating concentrations of pyridoxal 5'-phosphate | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | required | Rattus norvegicus | |
| pyridoxal 5'-phosphate | tightly bound to the apoenzyme. Non-competitive inhibition at high concentrations | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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