Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | more than 90% of GAD activity occurs in the cytosolic fraction. Isoform GAD67 is exclusively expressed in the cytosolic fraction | Rattus norvegicus | 5829 | - |
membrane | isoform GAD65 is localized to the membrane fraction | Rattus norvegicus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
67000 | - |
x * 67000, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | - |
Rattus norvegicus | 4-aminobutanoate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 67000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
GAD67 | - |
Rattus norvegicus |
glutamic acid decarboxylase 67 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | exposure of cell cultures to intermittent hypoxia decreases GAD67 activity. intermittent hypoxia-evoked decrease in GAD67 activity is caused by increased cAMP - protein kinase A - dependent phosphorylation of GAD67, but not as a result of changes in either GAD67 mRNA or protein expression | additional information |