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Literature summary for 4.1.1.15 extracted from

  • Raghuraman, G.; Prabhakar, N.R.; Kumar, G.K.
    Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling (2010), J. Neurochem., 115, 1568-1578.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol more than 90% of GAD activity occurs in the cytosolic fraction. Isoform GAD67 is exclusively expressed in the cytosolic fraction Rattus norvegicus 5829
-
membrane isoform GAD65 is localized to the membrane fraction Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
67000
-
x * 67000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
Rattus norvegicus 4-aminobutanoate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 67000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
GAD67
-
Rattus norvegicus
glutamic acid decarboxylase 67
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus exposure of cell cultures to intermittent hypoxia decreases GAD67 activity. intermittent hypoxia-evoked decrease in GAD67 activity is caused by increased cAMP - protein kinase A - dependent phosphorylation of GAD67, but not as a result of changes in either GAD67 mRNA or protein expression additional information