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Literature summary for 4.1.1.15 extracted from

  • Miyazato, M.; Sugaya, K.; Goins, W.F.; Wolfe, D.; Goss, J.R.; Chancellor, M.B.; de Groat, W.C.; Glorioso, J.C.; Yoshimura, N.
    Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats (2009), Gene Ther., 16, 660-668.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine herpes simplex virus -based GAD gene transfer to bladder afferent pathways represents an approach for treatment of neurogenic detrusor overactivity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Rattus norvegicus
-
 4-aminobutanoate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dorsal root ganglion
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Rattus norvegicus 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD67 67 kDa form of the glutamic acid decarboxylase Rattus norvegicus
glutamic acid decarboxylase 67 67 kDa form of the glutamic acid decarboxylase Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus in the herpes simplex virus-GAD group, GAD67 mRNA and protein levels are significantly increased in the L6-S1 dorsal root ganglia up