Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.15 extracted from

  • Bergado-Acosta, J.R.; Sangha, S.; Narayanan, R.T.; Obata, K.; Pape, H.C.; Stork, O.
    Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory (2008), Learn. Mem., 15, 163-171.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.15

Cloned(Commentary)

Cloned (Comment) Organism
genes GAd65 and GAD67, expression analysis in brain tissues Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information targeted ablation of the GAD65 gene in Gad65-/- mice results in a pronounced context-independent, intramodal generalization of auditory fear memory during long-term/24 h or 14 d but not short-term/30 min memory retrieval, phenotype analysis, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Mus musculus GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65-/- mice during the expression of generalized fear memory 4-aminobutanoate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57BI/6 mice, genes GAD65 and GAD67 encoding the 65-kDa and the 67-kDa isozymes of glutamic acid decarboxylase
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Mus musculus
-
brain
-
 Mus musculus
-
hippocampus dorsal Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Mus musculus 4-aminobutanoate + CO2
-
 ?
L-glutamate GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65-/- mice during the expression of generalized fear memory Mus musculus 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD65
-
 Mus musculus
GAD67
-
 Mus musculus
Glutamic acid decarboxylase
-
 Mus musculus