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Literature summary for 4.1.1.15 extracted from
- Anti-glutamic acid decarboxylase antibody in Graves' disease is a possible indicator for the unlikelihood of going into remission with antithyroid agents (2009), Endocr. J., 56, 269-274.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | GAD65 is a predictive marker for the insulin depletion in diabetes mellitus | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | Homo sapiens | the isozymes are involved in autoimmune response and diseases, such as diabetes mellitus and Graves' disease, overview. Correlations between anti-GAD autoantibodies and diseases, overview | 4-aminobutanoate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
two isozymes Gad65 and GAd67, male and female Graves' disease patients | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| pancreatic beta cell | isozyme GAD65 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | - |
Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | the isozymes are involved in autoimmune response and diseases, such as diabetes mellitus and Graves' disease, overview. Correlations between anti-GAD autoantibodies and diseases, overview | Homo sapiens | 4-aminobutanoate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD | - |
Homo sapiens |
| Glutamic acid decarboxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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