Any feedback?
Literature summary for 4.1.1.15 extracted from
- The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65 (1999), J. Biol. Chem., 274, 37200-37209.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of deletion mutant (rGAD65)C45A/DELTA1-38 and (rGAD65)DELTA1-101, expression in COS-7 cells | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| axon | - |
Rattus norvegicus | 30424 | - |
| membrane | three distinct moieties of glutamate decarboxylase localize to membrane compartments, an amphiphilic GAD65 homodimer, an amphiphilic GAD65/67 heterodimer, tethered to membranes via the GAD65 subunit and a hydrophilic GAD67 homodimer, which associates with membranes by a distinct mechanism | Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| nerve | nerve terminal | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD65 | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
