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Literature summary for 4.1.1.15 extracted from

  • Tursky, T.; Bandzuchova, E.
    An endogenous activator of renal glutamic acid decarboxylase effects of adenosine triphosphate, phosphate and chloride on the activity of this enzyme (1999), Eur. J. Biochem., 262, 696-703.
    View publication on PubMed
Search for more literature for 4.1.1.15

Activating Compound

Activating Compound Comment Organism Structure
ADP 2 mM, activation to about 170% of control without detergent. Activation to about 210% of control in presence of 1% Triton X-100 Rattus norvegicus
AMP 2 mM, activation to about 125% of control without detergent. Activation to about 140% of control in presence of 1% Triton X-100 Rattus norvegicus
ATP 2 mM, activation to about 150% of control in presence of 1% Triton, inhibition to 20% of control without detergent Rattus norvegicus
CTP 2 mM, activation to about 110% of control without detergent. Activation to about 200% of control in presence of 1% Triton X-100 Rattus norvegicus
GTP 2 mM, activation to about 125% of control without detergent. Activation to about 190% of control in presence of 1% Triton X-100 Rattus norvegicus
UTP 2 mM, activation to about 140% of control without detergent. Activation to about 190% of control in presence of 1% Triton X-100 Rattus norvegicus

General Stability

General Stability Organism
ATP and phosphate together with chlorides stabilize renal GAD Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ATP in presence of leupeptin in freshly prepared homogenates. Inhibition of enzyme from homogenates stored without Triton X-100 for 24 h at 4°C Rattus norvegicus
EGTA 0.5 mM, 20% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the renal enzyme differs from the brain and pancreatic enzyme by its strong binding to membranes that is not influenced by detergents Rattus norvegicus 16020
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Metals/Ions

Metals/Ions Comment Organism Structure
KBr 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
KCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
LiCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
NaBr 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus
NaCl 50 mM, enhances GAD activity in renal cortex homogenate Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
kidney the renal enzyme differs from the brain and pancreatic enzyme by its strong binding to membranes that is not influenced by detergents Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu
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 Rattus norvegicus 4-Aminobutanoate + CO2
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