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Literature summary for 4.1.1.15 extracted from

  • Prabhakaran, K.; Harris, E.B.; Kirchheimer, W.F.
    Glutamic acid decarboxylase in Mycobacterium leprae (1983), Arch. Microbiol., 134, 320-323.
    View publication on PubMed
Search for more literature for 4.1.1.15

Activating Compound

Activating Compound Comment Organism Structure
2-oxoglutarate stimulates Mycobacterium leprae
5,5'-dithiobis(2-nitrobenzoic acid) stimulates Mycobacterium leprae
Glutarate stimulates Mycobacterium leprae

Inhibitors

Inhibitors Comment Organism Structure
Aminoethylylisothiouronium bromide
-
 Mycobacterium leprae
D-Glu
-
 Mycobacterium leprae
DL-alpha-Methylglutamate
-
 Mycobacterium leprae
glutathione
-
 Mycobacterium leprae
hydroxylamine
-
 Mycobacterium leprae
oxaloacetate
-
 Mycobacterium leprae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-values depending on buffer Mycobacterium leprae

Organism

Organism UniProt Comment Textmining
Mycobacterium leprae
-
 spleen from Dasypus novemcinctus infected with Mycobacterium leprae
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information spleen from Dasypus novemcinctus infected with Mycobacterium leprae Mycobacterium leprae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu
-
 Mycobacterium leprae 4-Aminobutanoate + CO2
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 10 min, little loss of activity Mycobacterium leprae
60
-
 10 min, over 50% loss of activity Mycobacterium leprae
80
-
 10 min, complete inactivation Mycobacterium leprae

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Mycobacterium leprae