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Literature summary for 4.1.1.15 extracted from
- L-Glutamate decarboxylase from bacteria (1985), Methods Enzymol., 113, 11-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Br- | activates | Escherichia coli |  |
| Cl- | activates | Escherichia coli | |
| F- | activates | Escherichia coli | |
| I- | activates | Escherichia coli | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cycloglutamates | - |
Escherichia coli | |
| Substituted dicarboxylic acids | - |
Escherichia coli |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.5 | 1.9 | L-Glu | at pH 4.6 | Escherichia coli | |
| 0.6 | - |
L-Glu | - |
Clostridium perfringens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
6 * 50000 | Escherichia coli |
| 290000 | - |
- |
Clostridium perfringens |
| 310000 | - |
equilibrium sedimentation | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium perfringens | - |
- |
- |
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 67.9 | - |
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alpha-Methylglutamate | - |
Escherichia coli | ? | - |
? | |
| L-Glu | - |
Escherichia coli | 4-Aminobutanoate + CO2 | - |
? | |
| L-Glu | - |
Clostridium perfringens | 4-Aminobutanoate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 50000 | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 4.5 | - |
Escherichia coli |
| 4.7 | - |
- |
Clostridium perfringens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | one molecule of pyridoxal 5'-phosphate is covalently bound to a lysyl residue | Escherichia coli | |
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