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Literature summary for 4.1.1.1 extracted from

  • Kondo, T.; Tezuka, H.; Ishii, J.; Matsuda, F.; Ogino, C.; Kondo, A.
    Genetic engineering to enhance the Ehrlich pathway and alter carbon flux for increased isobutanol production from glucose by Saccharomyces cerevisiae (2012), J. Biotechnol., 159, 32-37.
    View publication on PubMed

Application

Application Comment Organism
synthesis in order to increase production of isobutanol, 2-oxoacid decarboxylase (KDC) and alcohol dehydrogenase (ADH) are expressed in Saccharomyces cerevisiae to enhance the endogenous activity of the Ehrlich pathway. Overexpression Ilv2, which catalyzes the first step in the valine synthetic pathway, and deletion of the PDC1 gene encoding a major pyruvate decarboxylase alters the abundant ethanol flux via pyruvate. Along with modification of culture conditions, the isobutanol titer is elevated 13fold, from 11 mg/l to 143 mg/l, and the yield is 6.6 mg/g glucose Lactococcus lactis

Cloned(Commentary)

Cloned (Comment) Organism
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Lactococcus lactis

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
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-
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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Lactococcus lactis
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Synonyms

Synonyms Comment Organism
KivD
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Lactococcus lactis