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Literature summary for 3.7.1.3 extracted from
- Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata (2012), Bioorg. Med. Chem. Lett., 22, 3398-3401.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lanthellamide | about 60% residual activity at 1 mM, about 80% residual activity at 0.5 mM, slight inhibition at 0.125 mM | Rattus norvegicus |  |
| additional information | lanthellamide does not inhibit the enzyme at concentrations up to 0.0625 mM | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-alanine | - |
? | |
| L-kynurenine + H2O | - |
Rattus norvegicus | anthranilate + L-alanine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Kynase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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