Literature summary for 3.7.1.3 extracted from

Christensen, M.; Duno, M.; Lund, A.M.; Skovby, F.; Christensen, E.
Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase (2007), J. Inherit. Metab. Dis., 30, 248-255.

Search for more literature for 3.7.1.3

Application

Application	Comment	Organism
medicine	xanthurenic aciduria is linked to a mutation in the gene encoding kynureninase	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
T198A	screening of cDNA from KYNU revealed homozygosity for a c.593A>G substitution in exon 7 in the proband, leading to a threonine-to-alanine shift, T198A, in kynureninase	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-kynurenine + H2O	Homo sapiens	-	anthranilate + L-alanine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	the catalytic activity of kynureninase is very low in most tissue with exception of liver and kidney	Homo sapiens	-
liver	the catalytic activity of kynureninase is very low in most tissue with exception of liver and kidney	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-kynurenine + H2O	-	Homo sapiens	anthranilate + L-alanine	-	?

Synonyms

Synonyms	Comment	Organism
kynureninase	-	Homo sapiens

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Release 2023.1 (January 2023)