Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | kynurenine induces both tryptophan oxygenase and kynureninase of the catabolic pathway of L-tryptophan degradation | Priestia megaterium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | catabolite repression of the pathway by glucose and glutamate, arginine does not cause repression | Priestia megaterium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + H2O | Priestia megaterium | the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview | anthranilate + L-alanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Priestia megaterium | - |
strain ATCC 19213 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture condition:L-tryptophan-grown cell | cells grown in a medium containing L-tryptophan as the sole carbon, nitrogen, and energy source | Priestia megaterium | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
poor activity in cells grown on arginine and on glucose, also in presence of L-tryptophan | Priestia megaterium |
4.4 | - |
cells grown on L-asparagine | Priestia megaterium |
8.8 | - |
cells grown on L-arginine | Priestia megaterium |
10.3 | - |
cells grown on L-alanine | Priestia megaterium |
31.25 | - |
cells grown on L-tryptophan | Priestia megaterium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + H2O | - |
Priestia megaterium | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview | Priestia megaterium | anthranilate + L-alanine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Priestia megaterium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Priestia megaterium |