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Literature summary for 3.7.1.3 extracted from

  • Stevens, J.L.
    Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity (1985), J. Biol. Chem., 260, 7945-7950.
    View publication on PubMed
Search for more literature for 3.7.1.3

Application

Application Comment Organism
medicine NAD+ biosynthesis Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 L-3-hydroxykynurenine
-
 Rattus norvegicus
0.4
-
 L-kynurenine
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 2 * 55000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O Rattus norvegicus
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.25
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O
-
 Rattus norvegicus anthranilate + L-alanine
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 55000, SDS-PAGE Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus