Application | Comment | Organism |
---|---|---|
medicine | tryptophan metabolism | Cavia porcellus |
medicine | tryptophan metabolism | Mus musculus |
medicine | tryptophan metabolism | Homo sapiens |
medicine | tryptophan metabolism | Rattus norvegicus |
medicine | tryptophan metabolism | Saccharomyces cerevisiae |
medicine | tryptophan metabolism | Bos taurus |
medicine | tryptophan metabolism | Neurospora crassa |
medicine | tryptophan metabolism | Aspergillus niger |
medicine | tryptophan metabolism | Pseudomonas fluorescens |
medicine | tryptophan metabolism | Canis lupus familiaris |
medicine | tryptophan metabolism | Pseudomonas marginalis |
medicine | tryptophan metabolism | Penicillium roqueforti |
medicine | tryptophan metabolism | Chondrichthyes |
medicine | tryptophan metabolism | aves |
medicine | tryptophan metabolism | Rhizopus stolonifer |
medicine | tryptophan metabolism | Xanthomonas arboricola pv. pruni |
medicine | tryptophan metabolism | Testudines |
medicine | tryptophan metabolism | amphibia |
Crystallization (Comment) | Organism |
---|---|
- |
Neurospora crassa |
- |
Pseudomonas fluorescens |
- |
Pseudomonas marginalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cadaverine | - |
Neurospora crassa | |
delta-N-acetyl-L-ornithine | - |
Neurospora crassa | |
delta-N-acetyl-L-ornithine | - |
Pseudomonas marginalis | |
DL-dihydroxyphenylalanine | - |
Neurospora crassa | |
HgCl2 | - |
Neurospora crassa | |
HgCl2 | - |
Pseudomonas marginalis | |
L-lysine | - |
Neurospora crassa | |
L-ornithine | - |
Neurospora crassa | |
L-ornithine | - |
Pseudomonas marginalis | |
NH2OH | - |
Neurospora crassa | |
NH2OH | - |
Pseudomonas marginalis | |
p-chloromercuribenzoate | - |
Neurospora crassa | |
p-chloromercuribenzoate | - |
Pseudomonas marginalis | |
phenylhydrazine-HCl | - |
Neurospora crassa | |
phenylhydrazine-HCl | - |
Pseudomonas marginalis | |
putrescine | - |
Neurospora crassa | |
pyridoxal 5'-phosphate | - |
Neurospora crassa | |
Sodium borohydride | - |
Neurospora crassa | |
Sodium borohydride | - |
Pseudomonas marginalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
3-hydroxy-L-kynurenine | - |
Neurospora crassa | |
0.006 | - |
kynurenine | - |
Neurospora crassa | |
0.0067 | - |
L-kynurenine | constitutive enzyme | Saccharomyces cerevisiae | |
0.018 | - |
L-kynurenine | - |
Xanthomonas arboricola pv. pruni | |
0.034 | - |
L-kynurenine | constitutive enzyme | Neurospora crassa | |
0.035 | - |
L-kynurenine | - |
Pseudomonas marginalis | |
0.037 | - |
L-3-hydroxykynurenine | constitutive enzyme | Neurospora crassa | |
0.039 | 0.0714 | L-kynurenine | - |
Pseudomonas fluorescens | |
0.05 | - |
L-3-hydroxykynurenine | - |
Pseudomonas fluorescens | |
0.2 | - |
L-3-hydroxykynurenine | - |
Pseudomonas marginalis | |
0.22 | - |
L-3-hydroxykynurenine | - |
Xanthomonas arboricola pv. pruni | |
0.54 | - |
L-3-hydroxykynurenine | constitutive enzyme | Saccharomyces cerevisiae | |
2.2 | - |
N'-formyl-L-kynurenine | - |
Pseudomonas fluorescens | |
2.2 | - |
N'-formyl-L-kynurenine | - |
Pseudomonas marginalis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Neurospora crassa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
2 * 46000, SDS-PAGE | Pseudomonas marginalis |
50000 | - |
2 * 50000 | Neurospora crassa |
92000 | - |
gel filtration | Pseudomonas marginalis |
100000 | - |
sedimentation equilibrium method | Pseudomonas marginalis |
105000 | - |
gel filtration | Neurospora crassa |
110000 | - |
constitutive and inducible enzyme, gel filtration | Neurospora crassa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-L-kynurenine + H2O | Cavia porcellus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Mus musculus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Homo sapiens | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Rattus norvegicus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Saccharomyces cerevisiae | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Bos taurus | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Neurospora crassa | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Aspergillus niger | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Pseudomonas fluorescens | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Canis lupus familiaris | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Pseudomonas marginalis | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Penicillium roqueforti | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Chondrichthyes | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | aves | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Rhizopus stolonifer | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Xanthomonas arboricola pv. pruni | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | Testudines | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | amphibia | - |
3-hydroxyanthranilate + L-Ala | - |
? | |
L-kynurenine + H2O | Cavia porcellus | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Mus musculus | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Homo sapiens | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Rattus norvegicus | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Saccharomyces cerevisiae | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Bos taurus | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Neurospora crassa | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Aspergillus niger | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Pseudomonas fluorescens | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Canis lupus familiaris | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Pseudomonas marginalis | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Penicillium roqueforti | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Chondrichthyes | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | aves | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Rhizopus stolonifer | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Xanthomonas arboricola pv. pruni | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | Testudines | - |
anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | amphibia | - |
anthranilate + L-alanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
amphibia | - |
- |
- |
Aspergillus niger | - |
- |
- |
aves | - |
- |
- |
Bos taurus | - |
- |
- |
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Chondrichthyes | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Neurospora crassa | - |
- |
- |
Penicillium roqueforti | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Pseudomonas marginalis | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rhizopus stolonifer | - |
- |
- |
Saccharomyces cerevisiae | - |
constitutive enzyme | - |
Testudines | - |
- |
- |
Xanthomonas arboricola pv. pruni | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
- |
Pseudomonas fluorescens |
- |
Pseudomonas marginalis |
- |
Xanthomonas arboricola pv. pruni |
constitutive and inducible enzyme | Neurospora crassa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
liver | - |
Canis lupus familiaris | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0178 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-L-kynurenine + H2O | - |
Cavia porcellus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Mus musculus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Homo sapiens | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Saccharomyces cerevisiae | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Bos taurus | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Neurospora crassa | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Aspergillus niger | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Pseudomonas fluorescens | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Canis lupus familiaris | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Pseudomonas marginalis | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Penicillium roqueforti | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Chondrichthyes | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
aves | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rhizopus stolonifer | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Xanthomonas arboricola pv. pruni | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Testudines | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
amphibia | 3-hydroxyanthranilate + L-alanine | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Cavia porcellus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Mus musculus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Homo sapiens | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rattus norvegicus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Saccharomyces cerevisiae | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Bos taurus | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Neurospora crassa | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Aspergillus niger | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Pseudomonas fluorescens | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Canis lupus familiaris | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Pseudomonas marginalis | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Penicillium roqueforti | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Chondrichthyes | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
aves | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Rhizopus stolonifer | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Xanthomonas arboricola pv. pruni | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
Testudines | 3-hydroxyanthranilate + L-Ala | - |
? | |
3-hydroxy-L-kynurenine + H2O | - |
amphibia | 3-hydroxyanthranilate + L-Ala | - |
? | |
L-kynurenine + H2O | - |
Cavia porcellus | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Mus musculus | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Homo sapiens | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Rattus norvegicus | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Saccharomyces cerevisiae | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Bos taurus | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Neurospora crassa | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Aspergillus niger | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Pseudomonas fluorescens | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Canis lupus familiaris | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Pseudomonas marginalis | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Penicillium roqueforti | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Chondrichthyes | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
aves | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Rhizopus stolonifer | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Xanthomonas arboricola pv. pruni | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
Testudines | anthranilate + L-alanine | - |
? | |
L-kynurenine + H2O | - |
amphibia | anthranilate + L-alanine | - |
? | |
N-formyl-L-kynurenine + H2O | - |
Neurospora crassa | N-formylanthranilate + L-alanine | - |
? | |
N-formyl-L-kynurenine + H2O | - |
Pseudomonas fluorescens | N-formylanthranilate + L-alanine | - |
? | |
N-formyl-L-kynurenine + H2O | - |
Pseudomonas marginalis | N-formylanthranilate + L-alanine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Rattus norvegicus |
dimer | 2 * 46000, SDS-PAGE | Pseudomonas marginalis |
dimer | 2 * 50000 | Neurospora crassa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Rattus norvegicus |
8 | - |
- |
Pseudomonas marginalis |
8.5 | - |
- |
Pseudomonas fluorescens |
8.5 | - |
constitutive enzyme | Neurospora crassa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
pyridoxal 5'-phosphate | - |
Neurospora crassa | |
pyridoxal 5'-phosphate | - |
Pseudomonas fluorescens | |
pyridoxal 5'-phosphate | - |
Pseudomonas marginalis |