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Literature summary for 3.7.1.3 extracted from

  • Knox, W.E.
    The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency (1952), Biochem. J., 53, 379-385.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.7.1.3

Application

Application Comment Organism
medicine tryptophan metabolism Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Rattus norvegicus
-
 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O Rattus norvegicus
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.005
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Rattus norvegicus 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O
-
 Rattus norvegicus anthranilate + L-alanine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus