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Literature summary for 3.7.1.3 extracted from

  • Jacoby, W.B.; Bonner, D.M.
    Kynureninase from Neurospora: Interaction of enzyme with substrates, coenzyme, and amines (1953), J. Biol. Chem., 205, 709-715.
    View publication on PubMed
Search for more literature for 3.7.1.3

Inhibitors

Inhibitors Comment Organism Structure
beta-Alanine competitive inhibition, 10 mM Neurospora crassa
cadaverine competitive inhibition, 10 mM Neurospora crassa
D-alanine competitive inhibition, 10 mM Neurospora crassa
D-serine competitive inhibition, 10 mM Neurospora crassa
DL-allothreonine competitive inhibition, 10 mM Neurospora crassa
DL-alpha-aminobutyric acid competitive inhibition, 10 mM Neurospora crassa
DL-dihydroxyphenylalanine competitive inhibition, 5 mM Neurospora crassa
DL-homoserine competitive inhibition, 10 mM Neurospora crassa
DL-methionine competitive inhibition, 40 mM Neurospora crassa
DL-Ornithine competitive inhibition, 10 mM Neurospora crassa
kynurenine
-
 Neurospora crassa
L-alanine competitive inhibition, 40 mM Neurospora crassa
L-arginine competitive inhibition, 10 mM Neurospora crassa
L-asparagine competitive inhibition, 10 mM Neurospora crassa
L-aspartic acid competitive inhibition, 10 mM Neurospora crassa
L-cysteine competitive inhibition, 10 mM Neurospora crassa
L-Glutamic acid competitive inhibition, 10 mM Neurospora crassa
L-glutamine competitive inhibition, 10 mM Neurospora crassa
L-histidine competitive inhibition, 10 mM Neurospora crassa
L-lysine competitive inhibition, 10 mM Neurospora crassa
L-serine competitive inhibition, 10 mM Neurospora crassa
L-threonine competitive inhibition, 10 mM Neurospora crassa
L-tryptophan competitive inhibition, 10 mM Neurospora crassa
putrescine competitive inhibition, 10 mM Neurospora crassa
pyridoxal 5'-phosphate
-
 Neurospora crassa
tryptamine competitive inhibition, 10 mM Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Neurospora crassa
-
 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O Neurospora crassa
-
 anthranilate + L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10
-
-
 Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-alanine
-
 ?
3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-Ala
-
 ?
L-kynurenine + H2O
-
 Neurospora crassa anthranilate + L-alanine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Neurospora crassa N-formylanthranilate + L-alanine
-
 ?