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Literature summary for 3.6.5.1 extracted from

  • Koester, M.; DellOrco, D.; Koch, K.W.
    The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes (2014), FEBS J., 281, 5175-5185.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
photoreceptor cell
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Bos taurus
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retina
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Bos taurus
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rod inner segment only under intense illumination Bos taurus
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Synonyms

Synonyms Comment Organism
transducin
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Bos taurus

General Information

General Information Comment Organism
metabolism the interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes, association of transducin and rhodopsin occurs with higher affinity and speed than the binding of Rac1 to rhodopsin. In dark-adapted rod cells, Rac1 cannot compete with transducin for binding to rhodopsin, and signalling can proceed normally. The concentration of transducin has to drop significantly so that Rac1 can bind to rhodopsin, in the outer segment, this occurs only under intense illumination, when transducin is translocated to the inner segment Bos taurus