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Literature summary for 3.6.5.1 extracted from

  • Baker, S.A.; Martemyanov, K.A.; Shavkunov, A.S.; Arshavsky, V.Y.
    Kinetic mechanism of RGS9-1 potentiation by R9AP (2006), Biochemistry, 45, 10690-10697.
    View publication on PubMed
Search for more literature for 3.6.5.1

Activating Compound

Activating Compound Comment Organism Structure
RGS9-1 protein short splice variant of RGS9, in complex with type 5 G protein beta-subunit Gbeta5L, regulated by the membrane anchor R9AP Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
 GTP illuminated uROS is used as source of photoexited rhodopsin required for transducin activation Bos taurus
0.0079
-
 GTP illuminated V8-uROS is used as source of photoexited rhodopsin required for transducin activation Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Bos taurus
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal rod rod outer segment Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Bos taurus GDP + phosphate
-
 ?

Subunits

Subunits Comment Organism
heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Bos taurus

Synonyms

Synonyms Comment Organism
GTP phosphohydrolase
-
 Bos taurus
heterotrimeric G-protein GTPase
-
 Bos taurus
photoreceptor-specific G protein
-
 Bos taurus
transducin
-
 Bos taurus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
22 24 activity assay Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 activity assay Bos taurus