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Literature summary for 3.6.5.1 extracted from

  • Ross, B.M.; McLaughlin, M.; Roberts, M.; Milligan, G.; McCulloch, J.; Knowler, J.T.
    Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease (1993), Brain Res., 622, 35-42.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the relative levels of the G-protein alpha subunits GS alpha-L, GS alpha-S, Gialpha-1, Gialpha-2 and Goalpha are unchanged in membranes prepared from Alzheimer-diseased frontal cortex or hippocampus to control brains. The activity of the G-protein associated high affinity GTPase is reduced in the frontal cortex by 25% and in the hippocampus by 27% Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
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Homo sapiens GDP + phosphate
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