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Literature summary for 3.6.4.6 extracted from

  • Yoshimori, T.; Yamagata, F.; Yamamoto, A.; Mizushima, N.; Kabeya, Y.; Nara, A.; Miwako, I.; Ohashi, M.; Ohsumi, M.; Ohsumi, Y.
    The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells (2000), Mol. Biol., 11, 747-763.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.6

Cloned(Commentary)

Cloned (Comment) Organism
SKD1 cDNA amplified by reverse transcription-PCR Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
bafilomycin A
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ?
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
ATP + H2O Rattus norvegicus
-
 ADP + phosphate
-
 ?
ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 HeLa cells
-
Homo sapiens
-
 human epidermoid carcinoma A-431 cells
-
Homo sapiens
-
 human embryonic kidney HEK293 cells
-
Mus musculus
-
-
-
Rattus norvegicus
-
 rat
-
Rattus norvegicus
-
 rat hepatoma H-4-II-E cells
-
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Mus musculus
a
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Homo sapiens
a
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Rattus norvegicus
a
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Saccharomyces cerevisiae
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
ATP + H2O
-
 Rattus norvegicus ADP + phosphate
-
 ?
ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
p97ATPase
-
 Rattus norvegicus
SKD1
-
 Mus musculus
Vps4p
-
 Saccharomyces cerevisiae