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Literature summary for 3.6.4.10 extracted from

  • Araujo, T.L.; Borges, J.C.; Ramos, C.H.; Meyer-Fernandes, J.R.; Oliveira Junior, R.S.; Pascutti, P.G.; Foguel, D.; Palhano, F.L.
    Conformational changes in human Hsp70 induced by high hydrostatic pressure produce oligomers with ATPase activity but without chaperone activity (2014), Biochemistry, 53, 2884-2889.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Homo sapiens ADP + phosphate
-
?

Subunits

Subunits Comment Organism
More although monomeric Hsp70 is very sensitive to hydrostatic pressure, the protein does not return to its native state after removal of the pressure but instead forms oligomeric species that lose chaperone activity but retain ATPase activity, overview Homo sapiens

Synonyms

Synonyms Comment Organism
Hsp70
-
Homo sapiens

General Information

General Information Comment Organism
additional information conformational changes in human Hsp70 induced by high hydrostatic pressure produce oligomers with ATPase activity but without chaperone activity Homo sapiens