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Literature summary for 3.6.4.10 extracted from
- Inhibitors of the HSP90 molecular chaperone: current status (2006), Adv. Cancer Res., 95, 323-348.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Hsp90 is a molecular target for cancer therapy | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 17-(allylamino)-17-demethoxygeldanamycin | - |
Homo sapiens |  |
| 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride | - |
Homo sapiens | |
| 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride | - |
Homo sapiens | |
| cisplatin | - |
Homo sapiens | |
| CNF1010 | - |
Homo sapiens | |
| geldanamycin | inhibits hsp90 function in vitro at low micromolar concentrations via the interaction with the N-terminal ATP-binding domain of Hsp90, which results in destabilization of oncogenic client proteins via the proteasomal degradation pathway | Homo sapiens | |
| mycograb | - |
Homo sapiens | |
| novobiocin | analogs | Homo sapiens | |
| radicicol | and oxime drivatives | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Homo sapiens | hsp90 is responsible for controlling the conformation, stability, activation, intracellular disposition, and proteolytic turnover of numerous important proteins that are involved in cell growth differentiation and survival | ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O | hsp90 is responsible for controlling the conformation, stability, activation, intracellular disposition, and proteolytic turnover of numerous important proteins that are involved in cell growth differentiation and survival | Homo sapiens | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heat shock protein 90 | - |
Homo sapiens |
| Hsp90 | - |
Homo sapiens |
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