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Literature summary for 3.5.4.B9 extracted from
- APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase (2004), Nucleic Acids Res., 32, 2421-2429.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded viral DNA + H2O | Homo sapiens | cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') | uracil in single-stranded viral DNA + NH3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9HC16 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded viral DNA + H2O | cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') | Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
| additional information | the enzyme alone extensively deaminates cDNA independently of reverse transcriptase. The cDNA has to be free of its RNA template to allow deamination. Deoxycytosine or dCTP are poor substrates | Homo sapiens | ? | - |
? | |
| TTTCCCCGC + H2O | sequence with highest deamination rate | Homo sapiens | TTTCCUCGC + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APOBEC3G | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication | Homo sapiens |
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Release 2023.1 (January 2023)
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