Literature summary for 3.5.4.B9 extracted from

Pham, P.; Chelico, L.; Goodman, M.F.
DNA deaminases AID and APOBEC3G act processively on single-stranded DNA (2007), DNA Repair, 6, 689-692.

Search for more literature for 3.5.4.B9

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine in single-stranded viral DNA + H2O	Homo sapiens	the enzyme carries out processive cytosine deamination by randomly binding, sliding and jumping bidirectionally on single-stranded DNA. The deamination by the enzyme proceeds predominantly 3'->5', resulting in preferential deamination at the target located closer to the 5' end of substrate. The enzyme favors deamination at the 5'C residue in the hot-spot motif CCC	uracil in single-stranded viral DNA + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC16	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cytosine in single-stranded viral DNA + H2O	the enzyme carries out processive cytosine deamination by randomly binding, sliding and jumping bidirectionally on single-stranded DNA. The deamination by the enzyme proceeds predominantly 3'->5', resulting in preferential deamination at the target located closer to the 5' end of substrate. The enzyme favors deamination at the 5'C residue in the hot-spot motif CCC	Homo sapiens	uracil in single-stranded viral DNA + NH3	-	?

Synonyms

Synonyms	Comment	Organism
APOBEC3G	-	Homo sapiens

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Release 2023.1 (January 2023)