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Literature summary for 3.5.4.6 extracted from
- Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms (1998), J. Biol. Chem., 273, 35118-35125.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of AMPD1 and AMPD3 in Sf9 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| DELTAL96 | AMPD1 mutant, higher specific activity | Homo sapiens |
| DELTAM90 | AMPD3 mutant, lower specific activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
AMPD1, AMPD2 and AMPD3 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| expression of AMPD1 and AMPD3 in Sf9 cells | Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 125 | - |
delta M90 AMPD3 mutant | Homo sapiens |
| 865 | - |
wild-type AMPD3 | Homo sapiens |
| 1850 | - |
wild-type AMPD1 | Homo sapiens |
| 3112 | - |
DELTA L96 AMPD1 mutant | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + H2O | - |
Homo sapiens | IMP + NH3 | - |
? |  |
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Release 2023.1 (January 2023)
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