Literature summary for 3.5.4.4 extracted from

Toth, A.M.; Li, Z.; Cattaneo, R.; Samuel, C.E.
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR (2009), J. Biol. Chem., 284, 29350-29356.

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Organism

Organism	UniProt	Comment	Textmining

General Information

General Information	Comment	Organism
malfunction	apoptosis is enhanced in ADAR1-deficient cells following infection with wild type and V knockout measles virus but not following infection with C knockout measles virus or treatment with tumor necrosis factor-alpha or staurosporine	Homo sapiens
physiological function	ADAR1 is a proviral, antiapoptotic host factor in the context of measles virus infection. ADAR1 enhances the growth of measles virus. ADAR1 suppresses wild type and V knockout measles virus-induced apoptosis. ADAR1 does not protect against tumor necrosis factor-alpha- or staurosporine-induced apoptosis. ADAR1 suppresses wild type and V knockout measles virus-induced protein kinase regulated by RNA activation. ADAR1 suppresses interferon regulatory transcription factor-3 activation by wild type and V knockout measles viruses	Homo sapiens

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Release 2023.1 (January 2023)