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Literature summary for 3.5.4.4 extracted from

  • Alessandrini, L.; Ciuffreda, P.; Pavlovic, R.; Santaniello, E.
    Activity of adenosine deaminase and adenylate deaminase on adenosine and 2’, 3’-isopropylidene adenosine: role of the protecting group at different pH values (2008), Nucleosides Nucleotides Nucleic Acids, 27, 31-36.
    View publication on PubMed
Search for more literature for 3.5.4.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + H2O Bos taurus
-
 inosine + NH3
-
 ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 mucosa, commercial preparation
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.06
-
 substrate 2Â’,3Â’-O-isopropylidene adenosine, pH 4.0 Bos taurus
0.2
-
 substrate adenosine, pH 4.0 Bos taurus
0.5
-
 substrate 2Â’,3Â’-O-isopropylidene adenosine, pH 5.0 Bos taurus
0.5
-
 substrate adenosine, pH 5.0 Bos taurus
0.6
-
 substrate 2Â’,3Â’-O-isopropylidene adenosine, pH 6.0 Bos taurus
0.8
-
 substrate 2Â’,3Â’-O-isopropylidene adenosine, pH 8.0 Bos taurus
0.9
-
 substrate 2Â’,3Â’-O-isopropylidene adenosine, pH 7.0 Bos taurus
1
-
 substrate adenosine, pH 6.0 Bos taurus
1
-
 substrate adenosine, pH 7.0 Bos taurus
1.1
-
 substrate adenosine, pH 8.0 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-O-isopropylidene adenosine + H2O
-
 Bos taurus 2',3'-O-isopropylidene inosine + NH3
-
 ?
adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ir

Synonyms

Synonyms Comment Organism
adenosine deaminase
-
 Bos taurus
ciADA
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 8
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
4 8 ciADA activity on adenosine at pH values between 6.0 nd 8.0 remains constant and is lower at pH smaller than 6. The activity is not influenced by the presence of isoproylidene moiety in 2Â’,3Â’-O-isopropylidene adenosine within pH 5-8 range. Bos taurus