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Literature summary for 3.5.4.4 extracted from

  • Vistoli, G.; Pedretti, A.; Alessandrini, L.; Casati, S.; Ciuffreda, P.; Meroni, G.; Santaniello, E.
    Enhanced activity or resistance of adenosine derivatives towards adenosine deaminase-catalyzed deamination: Influence of ribose modifications (2009), Bioorg. Med. Chem. Lett., 19, 2877-2879.
    View publication on PubMed
Search for more literature for 3.5.4.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + H2O Bos taurus
-
 inosine + NH3
-
 ir

Organism

Organism UniProt Comment Textmining
Bos taurus P56658
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 no activity with substrate 9H-(1-deoxy-3,4-O-isopropylidene-beta-D-psicofuranosyl)adenine, adenosine deaminase aptly transforms substrates largely modified at the 2’- and 3’-O-positions, whereas C-modification at the 1’-position prevents the adenosine deaminase-catalyzed deamination Bos taurus
0.9
-
 enzymatic data, conformational properties and docking scores for adenosine analogue 2’,3’-O-isopropylidenadenosine, modeling studies Bos taurus
1
-
 substrate adenosine Bos taurus
2
-
 enzymatic data, conformational properties and docking scores for adenosine analogue 2’,3’-O-methoxymethylideneadenosine, modeling studies Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-O-isopropylidenadenosine + H2O modeling studies Bos taurus 2',3'-O-isopropylideninosine + NH3
-
 ?
2',3'-O-methoxymethylideneadenosine + H2O modeling studies Bos taurus 2',3'-O-methoxymethylideneinosine + NH3
-
 ?
adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ir

Synonyms

Synonyms Comment Organism
ADA
-
 Bos taurus