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Literature summary for 3.5.4.4 extracted from
- Relation of enzyme activity to local/global stability of murine adenosine deaminase: 19F NMR studies (2005), J. Mol. Biol., 345, 599-610.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-fluoro-D,L-tryptophan | adenosine analogue, induces conformational changes inhibiting the enzyme, structural mechanism, overview | Mus musculus |  |
| adenosine analogues | induce conformational changes inhibiting the enzyme, structural mechanism, overview | Mus musculus | |
| additional information | loss of activity precedes the global secondary and tertiary structure transition when the enzyme is exposed to denaturant, structural mechanism, overview | Mus musculus | |
| purine riboside | adenosine analogue, induces conformational changes inhibiting the enzyme, structural mechanism, overview | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | thermodynamics and kinetics | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc-metalloenzyme, binding structure | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | Mus musculus | the enzyme is crucial for purine metabolism and normal immune competence | inosine + NH3 | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P03958 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | - |
Mus musculus | inosine + NH3 | - |
ir | |
| adenosine + H2O | the enzyme is crucial for purine metabolism and normal immune competence | Mus musculus | inosine + NH3 | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the enzyme has (beta/alpha)8-barrel structure with bound zinc | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADA | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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